How Nitric Oxide Supports Blood Flow and Endurance

Roma Kunde
Roma Kunde
March 11, 2025
10
min read
Technically reviewed by: 
Charisse Cartin
How Nitric Oxide Supports Blood Flow and Endurance
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Inside This Blog:

  • How Do Nitric Oxide and Circulation Affect Endurance and Recovery?
  • What Causes Low Nitric Oxide Levels?
  • What Are Low Nitric Oxide Symptoms?
  • How to Naturally Boost Nitric Oxide for Better Performance

Have you noticed how your muscles feel sluggish and take longer to recover after a high-intensity workout? That’s because endurance and recovery rely on proper blood circulation. At its center is a molecule called nitric oxide (NO). It helps blood vessels relax, allowing more oxygen to reach your muscles. More oxygen means better stamina, faster recovery, and less fatigue [1].

Factors like oxidative stress, poor diet, and overtraining can lower NO levels, making workouts feel harder. But you can naturally increase NO levels in your body through better dietary, exercise, and lifestyle choices [2].

Let’s explore how to increase nitric oxide in the blood naturally and maintain levels to support endurance.

How Do Nitric Oxide and Circulation Affect Endurance and Recovery?

Your muscles need a steady supply of oxygen and nutrients to keep going, and efficient circulation makes this possible. NO helps blood vessels widen, allowing more oxygen-rich blood to reach your muscles. This improves stamina, delays fatigue, and speeds up recovery [1].

Your body produces NO in the cells lining your blood vessels using an amino acid called L-arginine [2]. When NO levels are high, blood flows more easily, allowing your muscles to get enough oxygen to perform better and recover faster. Recent research shows that athletes with higher NO levels have better endurance and experience less fatigue [2-3].

But NO doesn't work alone. Your lungs play a crucial role in boosting your energy levels and endurance by giving your body the oxygen it needs. Lung function, specifically functional residual capacity (FRC), helps regulate how much oxygen is available for your body. FRC refers to the air that remains in your lungs even after you breathe out. This reserve allows your lungs to continue sending oxygen into your blood, supporting your muscles and stamina during workouts [4].

If your lungs' functional capacity and NO levels are low, less oxygen is available, causing you to feel tired more quickly. But healthy FRC and NO levels mean your lungs can deliver oxygen to your blood between breaths. This prevents your muscles from tiring during workouts [2-4].

Nitric oxide boosts circulation, delivering oxygen to muscles, while lung function helps sustain stamina and recovery.

What Causes Low Nitric Oxide Levels?

When NO levels drop, blood flow slows down. This can be due to oxidative stress, which occurs when harmful free radicals build up in the body and outnumber antioxidants. This imbalance damages the cells that produce NO, reducing its availability. As a result, blood vessels struggle to relax, affecting circulation [2].

A poor diet, pollution, smoking, intense exercise, and chronic stress can all increase oxidative stress. These factors make it harder for blood vessels to produce and maintain NO levels. Over time, it can take a toll on your strength and overall performance [2].

What Are Low Nitric Oxide Symptoms?

If you have low NO levels, you may notice these signs of oxidative stress [2-5]:

  • Frequent muscle fatigue and slower recovery
  • Reduced endurance and stamina during workouts
  • Poor circulation and high blood pressure
  • Brain fog, memory problems, or trouble focusing
  • Poor metabolic and gut health
  • Sexual dysfunction
  • Increased inflammation and other signs of aging
  • Weakened immune function
Low nitric oxide levels can lead to fatigue, poor circulation, reduced endurance, brain fog, and weakened immune function.
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How to Naturally Boost Nitric Oxide for Better Performance

Boosting NO levels can be easy — your body produces it naturally. These simple lifestyle changes can help maintain optimal NO levels for improved performance:

1. Foods That Increase Nitric Oxide in the Blood

Beetroot juice is rich in natural nitrates, which your body converts into nitric oxide to improve blood flow and stamina.

The food you eat plays a key role in NO production. Beetroot, radish, and leafy greens like arugula are rich in natural nitrates, which your body converts into NO to enhance blood flow. Citrus fruits provide vitamin C, an antioxidant that helps boost NO levels and prevents breakdown [6-7].

L-arginine is the amino acid your body uses to produce NO. You can naturally include it in your diet through nuts, seeds, fish, red meat, soy, whole grains, beans, and dairy products [7-8]. Adding antioxidant-rich foods like berries and nuts to your diet can also help reduce oxidative stress and restore NO levels [9].

Your gut health matters, too. Good bacteria in your gut help convert dietary nitrates into NO more efficiently [10]. So, eating a balanced diet with NO-boosting foods can naturally enhance your blood flow and stamina.

2. Movement and Exercise for Better Nitric Oxide Production

Cycling boosts nitric oxide production, enhancing circulation, oxygen delivery, and endurance.

Exercise is a powerful way to increase NO levels. When you move, your blood vessels sense an increased demand for oxygen and release NO to improve circulation [1].

Aerobic exercises like running, cycling, and swimming keep your heart pumping and blood flowing, requiring sustained NO production. Resistance training, such as weightlifting, puts stress on the muscles, prompting the body to release NO. This helps blood vessels expand, improving oxygen flow, circulation, and recovery [1, 2, 11].

3. Breathing and Lung Function

Breathing can enhance NO production. Your nasal passages release NO, which relaxes blood vessels, opens the sinuses, and improves oxygen flow. Deep, controlled breathing enhances this effect while strengthening lung function for enhanced endurance. A higher FRC helps maintain a steady oxygen supply, reducing fatigue during workouts.

Simple practices like breath-hold exercises, nasal breathing, and humming while breathing can strengthen your lungs. This improves oxygen exchange and boosts NO levels. By improving lung function, you enhance circulation, vigor, and overall performance [12-13].

Breathing exercises enhance nitric oxide, lung function, and oxygen flow for better endurance.

Did You Know?
Humming during breathing is an ancient Yoga practice called Bhramari. It stimulates NO production naturally, improving circulation and enhancing oxygen delivery for peak performance and endurance [12]. Try it daily and feel the difference.

4. Supplements That Support Nitric Oxide Production

Supplements can be an easy way to support NO production, especially when diet and lifestyle alone aren’t enough. Certain nutrients, like L-arginine and L-citrulline, act as direct precursors to NO, promoting blood vessel relaxation and improving circulation. L-citrulline is particularly effective because the body converts it into L-arginine, which then boosts NO levels [7-8].

Antioxidants also help protect NO from being broken down by oxidative stress-causing free radicals. Vitamins C and E, along with polyphenols found in fruits and vegetables, help keep NO active in the body for longer [6-9].

But do NO-boosting supplements really work? Research suggests they can enhance strength, reduce fatigue, and improve blood flow. However, they’re most effective when combined with a healthy diet and regular exercise. Choosing high-quality supplements with clinically proven ingredients can give you an extra edge in performance and recovery [7, 11, 14].

Supplements like L-arginine and L-citrulline can help improve circulation, endurance, and recovery—especially when paired with a healthy diet and exercise.

Final Thoughts

Your body naturally produces NO, but its levels can decline over time. This can make it harder to maintain optimal blood flow and strength. Simple changes like eating nitrate-rich foods, staying active, and improving breathing can make a big difference in your energy levels. By making informed choices, you can take control of your health and feel your best.

Prioritize your health with Diagnox's Nitric Oxide Saliva Test Strips, a simple at-home test that checks for salivary nitric oxide levels, helping you make informed dietary and lifestyle choices.

Key Takeaways:

  1. Nitric oxide (NO) boosts circulation by relaxing blood vessels, improving oxygen delivery for greater endurance and faster recovery.
  2. Nitrate-rich foods like beets, leafy greens, and citrus naturally support NO production, helping maintain optimal blood flow.
  3. Aerobic exercises and resistance training stimulate NO release, enhancing overall physical strength and stamina.
  4. Breathing techniques such as deep nasal breathing or humming (Bhramari) can naturally increase NO levels, promoting better oxygenation.
  5. Simple lifestyle changes like a balanced diet, regular movement, and mindful breathing can improve NO levels for enhanced endurance.
References

[1] O. Oral, “Nitric oxide and its role in exercise physiology,” J. Sports Med. Phys. Fitness, vol. 61, pp. 1208-1211, Sep 2021.

[2] O. M. Shannon, T. Clifford, D. R. Seals, D. H. Craighead, and M. J. Rossman, “Nitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes,” Nitric Oxide, vol. 125-126, pp. 31-39, Aug 2022.

[3] J. D. Allen, “Nitric oxide as a mediator of exercise performance: NO pain NO gain,” Nitric Oxide, vol. 136-137, pp. 8-11. July 2023.

[4] M. F. Lutfi, “The physiological basis and clinical significance of lung volume measurements,” Multidiscip. Respir. Med., vol. 12, pp. 3, Feb 2017.

[5] Personalized Lifestyle Medicine Institute Staff, “Signs and Symptoms of Oral Dysbiosis & Low Nitric Oxide Levels,” Personalized Lifestyle Medicine Institute, Available Online. [Accessed Feb 13, 2025].

[6] D. Dos Santos Baião, D. Vieira Teixeira da Silva, and V. Margaret Flosi Paschoalin, “A Narrative Review on Dietary Strategies to Provide Nitric Oxide as a Non-Drug Cardiovascular Disease Therapy: Beetroot Formulations-A Smart Nutritional Intervention,” Foods., vol. 10, pp. 859. April 2021.

[7] USADA Staff, “Do Athletes Really Need Nitric Oxide Supplements to Boost Performance?,” USADA, Available Online. [Accessed Feb 13, 2025]

[8] Mayo Clinic Staff, “L-arginine: Does it lower blood pressure?,” Mayo Clinic, Available Online. [Accessed Feb 13, 2025].

[9] H. Tkaczenko and N Kurhaluk, “Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways,” Int. J. Mol. Sci., vol. 26, pp. 1098, Jan 2025.

[10] H. Liu, Y. Huang, M. Huang, M. Wang, Y. Ming, W. Chen, Y. Chen, Z. Tang, and B. Jia, “From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease,” Eur. J. Med. Res., vol. 28, pp. 425, Oct 2023.

[11] A. M. Gonzalez, J. R. Townsend, A. G. Pinzone, and J. R. Hoffman, “Supplementation with Nitric Oxide Precursors for Strength Performance: A Review of the Current Literature,” Nutrients, vol. 15, pp. 660, Jan 2023.

[12] K. Abishek, S. S. Bakshi, and A. B. Bhavanani, “The Efficacy of Yogic Breathing Exercise Bhramari Pranayama in Relieving Symptoms of Chronic Rhinosinusitis,” Int. J. Yoga, vol. 12, pp. 120-123, May-Aug 2019.

[13] Pacific College of Science and Health Staff, “The Link Between Qigong Breath Holding and Nitric Oxide,” Pacific College of Science and Health, Available Online. [Accessed Feb 13, 2025].

[14] M. McIntosh, R. Cochrum, R. Conners, V. Moreno, J. Smith, M. Black, and J. Heimdal, “The Effect of A Nitric Oxide Supporting Pre-workout Supplement On Muscular Endurance: 866,” Med. Sci. Sports Exerc., vol. 53, pp. 288, Aug 2021.

About the Author
Roma Kunde

Roma Kunde is a freelance content writer with a biotechnology and medical background. She has completed her B. Tech in Biotechnology and has a certificate in Clinical Research. She has 6 years of writing and editing experience in fields such as biomedical research, food/lifestyle, website content, marketing, and NGO services. She has written blog articles for websites related to construction chemicals, current affairs, marketing, medicine, and cosmetics.

About the Reviewer
This blog was
Technically reviewed by: 
Charisse Cartin

Charisse Cartin is a talented and dedicated editor who has contributed significantly to this blog.

The blog was also reviewed by the Diagnox content team. Diagnox Staff consists of a multidisciplinary team of scientists, content writers, and healthcare professionals with an expertise to create and review high-quality, informative, accurate, and easy-to-understand content for both professionals and everyday readers. Our staff follows strict guidelines to ensure the credibility and authenticity of the information, reviewing them independently and verifying them by various scientific and technical sources to ensure accuracy. Our review team believes in delivering knowledge free from bias to improve public health and well-being.

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